The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA- and protein-based programs for the potential treatment of neuromuscular and ocular diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Opportunity

We are seeking a dynamic and motivated Translational PK/PD Modeling Consultant who will bring extensive expertise in quantitative pharmacology. The ideal candidate will have a strong experience developing PK/PD models in rare diseases, within the biotechnology or pharmaceutical industry and be passionate about translating science into approved and accessible medicines, specifically within the Ocular space.

Responsibilities

Use modeling approaches to advance translational Ocular research at Entrada Therapeutics.
Support the development of translational PK/PD models, in collaboration with the Head of Clinical Pharmacology, to bring value to the Entrada portfolio.
Author regulatory documents including analysis plans, study reports, and modeling and simulation reports as needed.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

MS + 8 years/PhD +2 years in a relevant field like pharmaceutical sciences/ computational biology/pharmacometrics/applied mathematics.
Hands-on experience with modeling tools in the pharmaceutical/biotechnology industry.
Publication record demonstrating translational PK/PD experience is desired.
This position is a long-term, US remote-based contract role, with 15 - 25 hours/week expected.

Equal Opportunity Employer

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.